Professor at Children’s Hospital of Fudan University ,China
Dr. Yonghao Gui is a renowned Chinese pediatrician and academic leader in pediatric cardiology and child health. Born in Shanghai in 1958, he has devoted his career to advancing children’s healthcare through clinical practice, academic research, and institutional leadership. A graduate of Shanghai Medical University, Dr. Gui rose through clinical and academic ranks to become President of the Children’s Hospital at Fudan University and later Vice President and Executive Vice President of Fudan University. He has played a central role in developing China’s pediatric research infrastructure, with a special focus on congenital heart disease and neonatal health. As a leading figure in pediatrics, he has served as chairman of the Chinese Pediatric Association and chief editor of top pediatric journals. Widely published and respected, Dr. Gui has also represented China in global medical exchanges and training programs in the U.S., Japan, Germany, and Canada, contributing to international collaboration in pediatric care.
🔹Professional Profile
🏆Strengths for the Award
Prof. Dr. Yonghao Gui is a pioneering figure in pediatric medicine with over four decades of impactful clinical, academic, and research contributions. As a global authority in pediatric cardiology, he has advanced the understanding of congenital heart disease through groundbreaking work on genetic and epigenetic regulation, maternal-fetal health, and miRNA pathways. His translational research, including antioxidant therapies and early-life interventions, bridges basic science with clinical care, positioning him at the forefront of precision pediatrics. Beyond research, Dr. Gui has demonstrated transformative leadership as President of the Children’s Hospital at Fudan University and Vice President of Fudan University, where he significantly enhanced pediatric research infrastructure in China. He has also influenced national child health policy, chaired key pediatric associations, and mentored generations of researchers. His prolific publications, editorial leadership, and international collaborations underscore his commitment to excellence, global knowledge exchange, and improving pediatric outcomes for children worldwide.
🎓 Education
Dr. Yonghao Gui began his medical education at Shanghai Medical University, where he earned his Bachelor of Science in Medicine from 1978 to 1982. During his early professional years, he pursued further academic enrichment in molecular biology through a continuing education program at the same institution. From 1991 to 1995, he was a visiting clinical research fellow at the Children’s Hospital of Philadelphia under the China/CHOP Academic Exchange Program, enhancing his expertise in pediatric cardiology. Later, from 1997 to 1999, he pursued a Master of Science degree in clinical epidemiology through the International Clinical Epidemiology Network (INCLEN) at its Southeast Asia Training Center in Bangkok. His commitment to lifelong learning also includes advanced hospital management courses at the University of British Columbia, Japan’s Osaka City University, and Germany’s Berlin Heart Institute. This rich educational background laid the foundation for his leadership in pediatric research and healthcare management in China.
💼Professional Experience
Dr. Gui’s career spans over four decades of clinical, academic, and administrative excellence. He began as a resident at the Children’s Hospital of Shanghai Medical University and advanced to attending physician in pediatric cardiology. His international fellowship at the Children’s Hospital of Philadelphia enriched his clinical expertise. Upon return, he held leadership roles including Deputy Chief of Pediatrics and Cardiovascular Center. Rising steadily, he became Vice President, then President of the Children’s Hospital at Fudan University, and later served as Vice President and Executive Vice President of Fudan University. Dr. Gui directed the Research Institute at the Children’s Hospital and led national pediatric journals as editor-in-chief. He also chaired national pediatric associations and played a pivotal role in establishing the Neonatal Clinical Research Lab under the Ministry of Health. His professional trajectory reflects his dedication to child health, innovation in medical research, and excellence in institutional leadership within China’s top medical education systems.
Dr. Yonghao Gui’s research primarily focuses on pediatric cardiology, especially the molecular and genetic underpinnings of congenital heart disease (CHD). As principal investigator on numerous national and municipal projects, he has explored early prevention, genetic regulation, microRNA roles, and epigenetic mechanisms in cardiac development. His work also delves into maternal-fetal interactions affecting neonatal cardiac health, including the impact of maternal diet, obesity, and metabolic disorders. Notably, his studies on gene-environment interactions and miRNA-mediated pathways offer insights into CHD pathogenesis. Dr. Gui has led multi-year projects funded by the National Natural Science Foundation and China’s “Double First-Class” initiative, focusing on early childhood health maintenance, cardiac enhancers, and transcription factor regulation. His translational research often utilizes zebrafish models and single-cell analysis to bridge clinical pediatrics and molecular science. Through these efforts, Dr. Gui is advancing precision medicine approaches for early detection, prevention, and intervention in pediatric cardiovascular diseases.
📚 Publications Top Notes
Antioxidant Management to Protect Male Offspring from the Progression of MASLD Programmed by Maternal Obesity in Mice
Authors: Jialing Zhang, Jiayu Wang, Da Xu, Fang Wu, Yonghao Gui
Journal: The Journal of Nutritional Biochemistry
Summary:
This study explores how antioxidant supplementation during pregnancy can mitigate the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in male offspring of obese mice. The findings suggest that antioxidant treatment may reduce oxidative stress and hepatic lipid accumulation, thereby protecting the liver health of offspring affected by maternal obesity.
Promoting Glutathione Synthesis: A Possibility for Treating Cardiomyopathy Induced by a Maternal Western Diet
Authors: Jialing Zhang, Jiayu Wang, Da Xu, Yiting Gui, Fan Bai, Yu Huo, Li Cao, Yonghao Gui
Journal: Nutrients
Summary:
The study investigates the therapeutic potential of enhancing glutathione synthesis to treat cardiomyopathy in offspring exposed to a maternal Western diet. Results indicate that boosting antioxidant defense through glutathione pathways can improve heart structure and function in these mice, suggesting a preventative strategy for diet-induced cardiovascular programming.
Protective Effect of Antioxidants on Cardiac Function in Adult Offspring Exposed to Prenatal Overnutrition
Authors: Jialing Zhang, Li Cao, Wenji Wang, Yu Huo, Yuanzheng Zheng, Fang Wu, Yonghao Gui
Journal: Journal of Developmental Origins of Health and Disease
Summary:
This article reports on how prenatal antioxidant therapy helps preserve cardiac function in adult mice born to mothers with high-calorie diets. The study emphasizes that early nutritional interventions can buffer the long-term adverse effects of maternal overnutrition on cardiovascular health in offspring.
📌 Conclusion
Dr. Yonghao Gui stands as a pillar in pediatric medicine, seamlessly integrating clinical excellence, academic leadership, and groundbreaking research. With decades of contributions to pediatric cardiology, he has significantly advanced our understanding of congenital heart disease and its early prevention. His leadership roles at Fudan University and national pediatric associations underscore his commitment to enhancing healthcare infrastructure and medical education in China. Through cross-disciplinary and international collaborations, Dr. Gui has nurtured innovation in child health research and policy. His editorial work and textbook authorship reflect a deep dedication to shaping the next generation of pediatric professionals. Whether pioneering molecular studies or directing top-tier hospitals and academic units, Dr. Gui embodies the ideals of a clinician-scientist committed to societal well-being. His sustained impact across research, teaching, and leadership continues to inspire medical professionals and improve child health outcomes nationally and globally. He remains a respected voice in both China’s and the world’s pediatric communities.