Researcher | Instituto Estadual do Cérebro Paulo Niemeyer | Brazil
Dr. Bruno Marques Vieira’s research is centered on the intersecting fields of immunopharmacology, neuroimmunology, and tumor immunology, with a strong focus on understanding immune cell behavior in health and disease. His work explores the complex roles of eosinophils and neutrophils in inflammatory and tumor processes, particularly their contribution to immune regulation within the brain tumor microenvironment. By integrating in vivo, in vitro, and histopathological methodologies, his studies investigate immune cell signaling pathways, the dynamics of inflammation, and the pharmacological modulation of immune responses. Dr. Vieira’s research emphasizes the mechanisms through which immune cells interact with tumor cells and how these interactions can be harnessed to develop novel therapeutic strategies. His investigations aim to identify molecular targets and immune biomarkers that have potential relevance for glioblastoma and other neuroinflammatory or oncological conditions. With 18 publications, 57 citations, and an h-index of 5, Dr. Vieira contributes significantly to advancing translational immunology by bridging fundamental immunological discoveries with clinical applications in neuro-oncology, highlighting the therapeutic potential of immune modulation in cancer treatment. Through his research, he continues to advance scientific understanding of immune–tumor communication, inflammation, and pharmacological intervention, supporting the development of innovative approaches for treating brain cancers and other immune-mediated diseases.
Profiles: Scopus | ORCID
Featured Publications
1. Vieira, B. M., de São José, V. S., Soares, P. N., & Moura-Neto, V. (2023). Eosinophils induces glioblastoma cell suppression and apoptosis—Roles of GM-CSF and cysteinyl-leukotrienes. International Immunopharmacology
2. Kast, R. E., Vieira, B. M., & Silva, E. B. da. (2025). A New Adjuvant Treatment for Glioblastoma Using Aprepitant, Vortioxetine, Roflumilast and Olanzapine: The AVRO Regimen. International Journal of Molecular Sciences, 26(13), 6158.
3. Vieira, B. M., Paiva, M. B., Gaspar-Elsas, M. I., & Xavier-Elsas, P. P. (2025). Coordinated regulation of eosinophil production and migration by glucocorticoids, prostaglandins, and cysteinyl-leukotrienes. International Immunopharmacology, 148, 114067.
Cited by: 1
4. Vieira, B. M., Almeida, B. F., & Machado, M. P. (2025). Eosinophil and B-cell dynamics in the milky spots from Schistosoma mansoni-infected mice: comparison with spleen and bone marrow, and extramedullary eosinopoiesis. International Immunology, 37(3), 173–185.
Cited by: 1
5. de São José, V. S., Vieira, B. M., Neto, V. M., & Lima, L. M. (2024). Repurposing Osimertinib and Gedatolisib for Glioblastoma Treatment: Evidence of Synergistic Effects in an In Vitro Phenotypic Study. Pharmaceuticals, 17(12), 1623.
Cited by: 2