Best Review Paper Award
Smart ROS-Responsive Nanoparticles for Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives
| Ashutosh Rana |
| Affiliation |
Lovely Professional University |
| Country |
India |
| Article Title |
Smart ROS-Responsive Nanoparticles for Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives |
| Journal |
Current Pharmaceutical Research (CPR) |
| Publication Year |
2026 |
| DOI |
10.63785/cpr.2026.2.3.346370 |
| Scopus |
60560031900 |
| Documents |
1 |
| ORCID |
0009-0007-6609-7107 |
| Research Area |
Biomedical Sciences |
| Award Category |
Best Review Paper Award |
| Event |
Global Diseases Research Awards |
The Best Review Paper Award recognizes scholarly review publications that provide comprehensive examinations of scientific developments, integrate findings from existing literature, and identify emerging research directions within a particular discipline. The article Smart ROS-Responsive Nanoparticles for Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives examines the application of reactive oxygen species (ROS)-responsive nanotechnology in neurological drug delivery. [1]
Abstract
Neurodegenerative diseases are associated with progressive neuronal damage and complex pathological mechanisms, including oxidative stress, mitochondrial dysfunction, and excessive reactive oxygen species production. This review examines smart ROS-responsive nanoparticles as emerging platforms for targeted drug delivery in neurodegenerative disorders. It discusses the mechanisms through which oxidative environments can trigger drug release, different nanoparticle architectures, and strategies for improving therapeutic delivery across the blood–brain barrier. [1]
Keywords
ROS-Responsive Nanoparticles, Reactive Oxygen Species, Neurodegenerative Diseases, Nanomedicine, Oxidative Stress, Targeted Drug Delivery, Blood–Brain Barrier, Pharmaceutical Nanotechnology, Alzheimer’s Disease, Parkinson’s Disease. [2]
Introduction
Neurodegenerative diseases constitute a significant area of biomedical research because of their progressive effects on neuronal structure and function. Conditions such as Alzheimer’s disease and Parkinson’s disease involve multiple pathological processes, including oxidative stress, protein aggregation, and mitochondrial dysfunction. [1]
Scientific Background
Reactive oxygen species are chemically reactive oxygen-containing molecules involved in cellular signalling and metabolic processes. Under normal physiological conditions, antioxidant defence mechanisms regulate ROS levels. However, excessive ROS production or impaired antioxidant activity can contribute to oxidative stress and cellular damage.[3]
Research Methodology
The article adopts a review-based research approach to examine published literature concerning ROS-responsive nanoparticles and their potential applications in neurodegenerative diseases. The publication describes literature searches across PubMed/MEDLINE.[1]
Key Findings
The review discusses several ROS-responsive chemical systems and nanoparticle platforms that may support controlled therapeutic delivery. It examines polymeric nanoparticles, lipid-based carriers, metal–organic frameworks, dendrimers, and exosome-mimicking systems. The article also highlights approaches intended to improve drug transport across the blood–brain barrier and increase therapeutic targeting within neurological tissues. [1]
Research Contributions
The article contributes to biomedical and pharmaceutical literature by consolidating research on ROS-responsive nanoparticle technologies for neurodegenerative disease applications. It connects oxidative stress mechanisms with the development of responsive nanocarriers and targeted therapeutic delivery systems.[2]
Publications
The publication is co-authored by Ashutosh Rana and Anshi Kumari and examines the scientific literature on responsive nanoparticle systems, oxidative stress, neurodegeneration, and advanced drug-delivery technologies. The article provides a scholarly reference for researchers investigating pharmaceutical nanotechnology and emerging therapeutic strategies for neurological disorders. [1]
Scientific Impact
The review has relevance to ongoing research into advanced pharmaceutical delivery systems for neurological disorders. Its discussion of ROS-responsive materials provides insight into how disease-associated oxidative conditions may be incorporated into nanoparticle design.[1]
Award Suitability
The publication demonstrates characteristics relevant to consideration under the Best Review Paper Award category of the Global Diseases Research Awards. Its subject addresses an important biomedical research area involving oxidative stress, neurodegenerative disorders, and advanced pharmaceutical nanotechnology. [3]
Conclusion
The review article by Ashutosh Rana examines the emerging role of ROS-responsive nanoparticles in research on neurodegenerative diseases. Its discussion of oxidative stress, responsive chemical linkages, nanoparticle architectures, and targeted drug delivery provides an overview of important developments in pharmaceutical nanotechnology. [1]